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Pristane-induced arthritis in mice. V. Susceptibility to pristane-induced arthritis is determined by the genetic regulation of the T cell repertoire.

Arthritis and rheumatism - 1 Nov 1998

Wooley P H, Sud S, Whalen J D, Nasser S

Abstract excerpt

OBJECTIVE: Pristane-induced arthritis (PIA) is an experimental seropositive arthritis that is characterized by serologic and cellular immune abnormalities and is dependent on the presence of a competent CD4+ T cell population. We examined the regulation of PIA by genes of the major histocompatibility complex (MHC) and the Mls-1 loci to determine whether the selection of the T cells that infiltrate arthritic...

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PMID: 9811058
DOI: 10.1002/1529-0131(199811)41:11<2022::AID-ART18>3.0.CO;2-P

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