Article
Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica.
Particle and fibre toxicology - 9 Feb 2026
Janssen Lisa M F, de Ocampo Caroline, Kono Dwight H, Ronsmans Steven, Ghosh Manosij, Hoet Peter H M, Pollard K Michael, Mayeux Jessica M
Abstract excerpt
BACKGROUND: The mucosal origins hypothesis of rheumatoid arthritis (RA) posits that inhalant exposures, such as cigarette smoke and crystalline silica (c-silica), trigger immune responses in the lungs that contribute to joint disease onset. However, the relationship between inhalants, lung inflammation, and inflammatory arthritis remains poorly understood. RESULTS: This study compared the development of...
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