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Article

Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice.

Journal of autoimmunity - 1 Mar 2020

Johnson Benjamin M, Gaudreau Marie-Claude, Gudi Radhika, Brown Robert, Gilkeson Gary, Vasu Chenthamarakshan

Abstract excerpt

The risk of developing systemic lupus erythematosus (SLE) is about 9 times higher in women as compared to men. Our recent report, which used (SWRxNZB) F1 (SNF1) mouse model of spontaneous lupus, showed a potential link between immune response initiated in the gut mucosa at juvenile age (sex hormone independent) and SLE susceptibility. Here, using this mouse model, we show that gut microbiota contributes...

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Source

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Identifiers

PMID: 32019684
DOI: 10.1016/j.jaut.2020.102420
PMCID: PMC7204266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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