Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An indoleamine 2,3-dioxygenase-negative mutant is defective in stat1 DNA binding: differential response to IFN-gamma and IFN-alpha.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jul 2000

Sotero-Esteva W D, Wolfe D, Ferris M, Taylor M W

Abstract excerpt

We have previously reported the isolation of mutant cell lines from the human carcinoma line ME180 that are resistant to the antiproliferative effect of interferon-gamma (IFN-gamma). These cell lines were defective in the induction of indoleamine 2,3-dioxygenase (IDO), a key enzyme of tryptophan catabolism. One of these cell lines, 3B6A, was chosen for further study. This cell line was also defective in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chloramphenicol O-Acetyltransferase
Share to Drug Resistance, Multiple

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

Share to Interferon-alpha

Share to Interferon alpha-2

Share to STAT1 Transcription Factor

Share to Uterine Cervical Neoplasms

Share to Vesicular stomatitis Indiana virus

Source

Identifiers

PMID: 10926204
DOI: 10.1089/107999000414790

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An indoleamine 2,3-dioxygenase-negative mutant is defective in stat1 DNA binding: differential response to IFN-gamma and IFN-alpha.PMID 10926204Read ↗

Reversal of interferon-gamma-resistant phenotype by poly(I:C): possible involvement of ISGF2 (IRF1) in interferon-gamma-mediated induction of the IDO gene.Semantic proximity Read ↗

Isolation and characterization of a human STAT1 gene regulatory element. Inducibility by interferon (IFN) types I and II and role of IFN regulatory factor-1.Semantic proximity Read ↗

IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth.Semantic proximity Read ↗

Functional relevance of the conserved DNA-binding domain of STAT2.Semantic proximity Read ↗

Regulation of Indoleamine-3,5-dioxygenase 1 (IDO1) in Lung Epithelial Cells by Coronaviruses (SARS-CoV) and Cytokine SignalingSemantic proximity Read ↗

Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism.Semantic proximity Read ↗

A Small-Molecule Enhancer of Signal Transducer and Activator of Transcription 1 Transcriptional Activity Accentuates the Antiproliferative Effects of IFN-γ in Human Cancer CellsSemantic proximity Read ↗

Clinically relevant dimer interface mutants of STAT1 transcription factor exhibit differential gene expression.Semantic proximity Read ↗

Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene.Semantic proximity Read ↗

Interferon-resistant Human Melanoma Cells Are Deficient in ISGF3 Components, STAT1, STAT2, and p48-ISGF3γSemantic proximity Read ↗

A dominant negative mutant of an IFN regulatory factor family protein inhibits both type I and type II IFN-stimulated gene expression and antiproliferative activity of IFNs.Semantic proximity Read ↗

Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.