Article
IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1993
Thomas S M, Garrity L F, Brandt C R, Schobert C S, Feng G S, Taylor M W, Carlin J M, Byrne G I
Abstract excerpt
The role of indoleamine 2,3-dioxygenase (IDO) in IFN-gamma-mediated inhibition of intracellular parasite growth has been examined previously, although earlier work has been largely correlative. In this study, we defined more completely the role of IDO in the IFN-antimicrobial response. Two mutant cell lines, derived from ME180 cells and exhibiting reduced IDO activity (IR3B6A, IR3B6B) were characterized to...
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