Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversal of interferon-gamma-resistant phenotype by poly(I:C): possible involvement of ISGF2 (IRF1) in interferon-gamma-mediated induction of the IDO gene.

Journal of interferon research - 1 Feb 1994

Ozes O N, Taylor M W

Abstract excerpt

Indoleamine 2,3-dioxygenase (IDO) is induced in many cell lines by interferon-gamma (IFN-gamma) treatment. IDO mRNA increases rapidly from 4 h after IFN-gamma treatment to at least 24 h after treatment in ME180 cells. The IFN-gamma-resistant mutant of ME180, IR3B6B, expresses only one-sixth the amount of IDO message after IFN-gamma treatment and very low levels of IDO. However, pretreatment of these mutants with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Molecular Sequence Data

Share to Phenotype

Share to Phosphorylation

Share to Transcription Factors

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 8027591
DOI: 10.1089/jir.1994.14.25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversal of interferon-gamma-resistant phenotype by poly(I:C): possible involvement of ISGF2 (IRF1) in interferon-gamma-mediated induction of the IDO gene.PMID 8027591Read ↗

Reversal of an interferon-gamma-resistant phenotype by poly(I:C): possible role of double-stranded RNA-activated kinase in interferon-gamma signaling.Semantic proximity Read ↗

Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism.Semantic proximity Read ↗

An indoleamine 2,3-dioxygenase-negative mutant is defective in stat1 DNA binding: differential response to IFN-gamma and IFN-alpha.Semantic proximity Read ↗

Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene.Semantic proximity Read ↗

Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells.Semantic proximity Read ↗

Transcription factors induced by interferons alpha and gamma.Semantic proximity Read ↗

IDO mutants cross resistant to type I interferon retain p91-dependent gene induction.Semantic proximity Read ↗

Transcriptional control of metabolism by interferon regulatory factorsSemantic proximity Read ↗

Genetic control of the response to interferon.Semantic proximity Read ↗

Transcriptional Induction by Double-stranded RNA Is Mediated by Interferon-stimulated Response Elements without Activation of Interferon-stimulated Gene Factor 3Semantic proximity Read ↗

Cloning of a gene ( <i>RIG-G</i> ) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genesSemantic proximity Read ↗

Cytoplasmic localization of the interferon‐inducible protein that is encoded by the <i>AIM2</i> (absent in melanoma) gene from the 200‐gene familySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.