Article
Reversal of interferon-gamma-resistant phenotype by poly(I:C): possible involvement of ISGF2 (IRF1) in interferon-gamma-mediated induction of the IDO gene.
Journal of interferon research - 1 Feb 1994
Ozes O N, Taylor M W
Abstract excerpt
Indoleamine 2,3-dioxygenase (IDO) is induced in many cell lines by interferon-gamma (IFN-gamma) treatment. IDO mRNA increases rapidly from 4 h after IFN-gamma treatment to at least 24 h after treatment in ME180 cells. The IFN-gamma-resistant mutant of ME180, IR3B6B, expresses only one-sixth the a...
Topics
- 2-Aminopurine
- Base Sequence
- DNA-Binding Proteins
- Drug Resistance
- Gene Expression Regulation, Enzymologic
- Humans
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Interferon Regulatory Factor-1
- Interferon-gamma
- Molecular Sequence Data
- Phenotype
- Phosphoproteins
- Phosphorylation
- Poly I-C
- Regulatory Sequences, Nucleic Acid
- Transcription Factors
- Tryptophan Oxygenase
- Tumor Cells, Cultured