Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism.

doi:10.1007/BF00290655

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Article

Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism.

Molecular & general genetics : MGG - 1 Nov 1991

Feng G S, Dai W, Gupta S L, Werner-Felmayer G, Wachter H, Takikawa O, Taylor M W

Abstract excerpt

Our previous observations indicated that mutants partially resistant to IFN-gamma cytotoxicity were defective in the induction of indoleamine 2,3-dioxygenase, (IDO). Two mutants highly resistant to IFN-gamma were isolated following a second round of mutagenesis. The resistance to IFN-gamma was inversely correlated with the inducibility of IDO in these mutants. Moreover, several other IFN-gamma responsive genes,...

Topics

Blotting, Northern
Blotting, Southern
Blotting, Western
Cell Survival
DNA
DNA Probes
Drug Resistance
GTP Cyclohydrolase
Gene Expression Regulation
Genes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Indoleamine-Pyrrole 2,3,-Dioxygenase

Interferon-gamma

Mutation

RNA

Receptors, Immunologic

Receptors, Interferon

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 1720865
DOI: 10.1007/BF00290655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1720865-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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