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Article

Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism.

Molecular & general genetics : MGG - 1 Nov 1991

Feng G S, Dai W, Gupta S L, Werner-Felmayer G, Wachter H, Takikawa O, Taylor M W

Abstract excerpt

Our previous observations indicated that mutants partially resistant to IFN-gamma cytotoxicity were defective in the induction of indoleamine 2,3-dioxygenase, (IDO). Two mutants highly resistant to IFN-gamma were isolated following a second round of mutagenesis. The resistance to IFN-gamma was inversely correlated with the inducibility of IDO in these mutants. Moreover, several other IFN-gamma responsive genes,...

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PMID: 1720865
DOI: 10.1007/BF00290655

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