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Article

Clinically relevant dimer interface mutants of STAT1 transcription factor exhibit differential gene expression.

PloS one - 1 Jan 2013

Staab Julia, Herrmann-Lingen Christoph, Meyer Thomas

Abstract excerpt

A transition from a parallel to an antiparallel dimer configuration of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for interferon (IFN)-mediated signal transduction. However, the precise molecular mechanisms linking conformational changes to target gene activation by STAT1 are still largely unknown. In the present study, we have characterized, in more detail...

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Source

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Identifiers

PMID: 23922848
DOI: 10.1371/journal.pone.0069903
PMCID: PMC3724676

Genes

STAT1
GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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