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Article

Functional relevance of the conserved DNA-binding domain of STAT2.

The Journal of biological chemistry - 1 Apr 2005

Brierley Melissa M, Fish Eleanor N

Abstract excerpt

Several distinct type I interferon (IFN)-inducible STAT2-containing complexes have been identified. For the IFN-stimulated gene factor 3 (ISGF3), STAT1 and IRF-9 mediate IFN-stimulated response element (ISRE) binding, whereas STAT2 provides a potent transactivational domain. ISGF3-independent STAT2-containing complexes, specifically STAT2:1 and STAT2:3, bind a gamma-activated sequence (GAS)-like element, yet the...

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Source

Identifiers

PMID: 15668228
DOI: 10.1074/jbc.M500426200

Genes

STAT2
STAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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