Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells.

Journal of virology - 1 Jan 2011

Mao Richeng, Zhang Jiming, Jiang Dong, Cai Dawei, Levy Jessica M, Cuconati Andrea, Block Timothy M, Guo Ju-Tao, Guo Haitao

Abstract excerpt

Alpha interferon (IFN-α) is an approved medication for chronic hepatitis B. Gamma interferon (IFN-γ) is a key mediator of host innate and adaptive antiviral immunity against hepatitis B virus (HBV) infection in vivo. In an effort to elucidate the antiviral mechanism of these cytokines, 37 IFN-stimulated genes (ISGs), which are highly inducible in hepatocytes, were tested for their ability to inhibit HBV...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culture Media
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Hepatocytes

Share to Indoleamine-Pyrrole 2,3,-Dioxygenase

Share to Interferon-gamma

Share to Tryptophan

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 21084489
DOI: 10.1128/JVI.01998-10
PMCID: PMC3019998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells.PMID 21084489Read ↗

Lambda Interferon Inhibits Hepatitis B and C Virus ReplicationSemantic proximity Read ↗

Interferon-γ inhibits replication of subgenomic and genomic hepatitis C virus RNAsSemantic proximity Read ↗

Reversal of interferon-gamma-resistant phenotype by poly(I:C): possible involvement of ISGF2 (IRF1) in interferon-gamma-mediated induction of the IDO gene.Semantic proximity Read ↗

Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C.Semantic proximity Read ↗

Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.Semantic proximity Read ↗

Interferon‐inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication†Semantic proximity Read ↗

Differential Transcriptional Responses to Interferon-α and Interferon-γ in Primary Human HepatocytesSemantic proximity Read ↗

An indoleamine 2,3-dioxygenase-negative mutant is defective in stat1 DNA binding: differential response to IFN-gamma and IFN-alpha.Semantic proximity Read ↗

Interferon-lambda (IFN-λ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytesSemantic proximity Read ↗

Transcriptional control of metabolism by interferon regulatory factorsSemantic proximity Read ↗

HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cellsSemantic proximity Read ↗

Correlations of indoleamine 2,3-dioxygenase, interferon-λ3, and anti-HBs antibodies in hemodialysis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.