Article
Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene.
The Journal of biological chemistry - 19 Jul 1996
Chon S Y, Hassanain H H, Gupta S L
Abstract excerpt
Interferon (IFN)-gamma induces the expression of the indoleamine 2, 3-dioxygenase (INDO) gene in human cells, which plays a role in the inhibitory effect of IFN-gamma on intracellular pathogens and on cell proliferation. Earlier studies established that the IFN-gamma-inducible expression of the I...
Topics
- Base Sequence
- Binding Sites
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Consensus Sequence
- DNA-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Genetic Variation
- Humans
- Interferon Regulatory Factor-1
- Interferon-gamma
- Molecular Sequence Data
- NF-kappa B
- Phosphoproteins
- Recombinant Proteins
- Restriction Mapping
- STAT1 Transcription Factor
- Signal Transduction