Article
A dominant negative mutant of an IFN regulatory factor family protein inhibits both type I and type II IFN-stimulated gene expression and antiproliferative activity of IFNs.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1996
Thornton A M, Ogryzko V V, Dent A, Sharf R, Levi B Z, Kanno Y, Staudt L M, Howard B H, Ozato K
Abstract excerpt
Type I (alpha,beta) and type II (gamma) IFNs elicit antiproliferative and antiviral activities through two distinct transcription pathways involving 1) IRF family proteins and ISGF3, and 2) STAT1. We have employed a dominant negative strategy to study the role of IRF family proteins in eliciting the biologic activities of IFN. A truncated IRF protein retaining the DNA-binding domain (DBD) of ICSBP (a member of...
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