Article
Increased TNFA*2, but not TNFB*1, allele frequency in Spanish atopic patients.
Journal of investigational allergology & clinical immunology - 1 Jan 2000
Castro J, Tellería J J, Linares P, Blanco-Quirós A
Abstract excerpt
Tumor necrosis factor (TNF) is a potent proinflammatory cytokine involved in asthma and atopy. Increased TNF-alpha levels have been found in airway biopsies and bronchoalveolar lavage fluids from asthmatic patients. Constitutional variations in the TNF-alpha secretion levels in vitro are associated with molecular polymorphisms located within and around the TNF loci. Our study objective was to investigate the...
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