Article
Lack of association between atopic asthma and the tumor necrosis factor alpha-308 gene polymorphism in a Czech population.
Journal of investigational allergology & clinical immunology - 1 Jan 2002
Bucková Dana, Hollá Lydie Izakovicová, Vasků Anna, Znojil Vladimír, Vácha Jirí
Abstract excerpt
Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components. Several investigators have linked the tumor necrosis factor (TNF) genes and nearby markers located on chromosome 6p to atopy and asthma. A recent study has demonstrated that the TNF-alpha*2 allele of a polymorphism in the TNF-alpha gene promoter region (G-308 A) is associated with a higher risk...
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