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Article

Cadmium-inducible expression of the yeast GSH1 gene requires a functional sulfur-amino acid regulatory network.

The Journal of biological chemistry - 20 Oct 2000

Dormer U H, Westwater J, McLaren N F, Kent N A, Mellor J, Jamieson D J

Abstract excerpt

Glutathione (gamma-l-glutamyl-l-cysteinylglycine) is an important antioxidant molecule, helping to buffer the cell against free radicals and toxic electrophiles. Expression of the yeast GSH1 gene, encoding the first enzyme involved in glutathione biosynthesis, gamma-glutamylcysteine synthetase, is regulated by oxidants and the heavy metal cadmium at the level of transcription. We present evidence that the...

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Identifiers

PMID: 10921921
DOI: 10.1074/jbc.M004167200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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