Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system.

Free radical biology & medicine - 1 May 2016

Gostimskaya Irina, Grant Chris M

Abstract excerpt

Glutathione is an abundant, low-molecular-weight tripeptide whose biological importance is dependent upon its redox-active free sulphydryl moiety. Its role as the main determinant of thiol-redox control has been challenged such that it has been proposed to play a crucial role in iron-sulphur clusters maturation, and only a minor role in thiol redox regulation, predominantly as a back-up system for the cytoplasmic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Cytoplasm
Share to Cytosol

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione

Share to Glutathione Reductase

Share to Iron-Sulfur Proteins

Share to Sulfhydryl Compounds

Share to Thioredoxins

Source

Open in PubMed Open full text

Identifiers

PMID: 26898146
DOI: 10.1016/j.freeradbiomed.2016.02.015
PMCID: PMC4851219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system.PMID 26898146Read ↗

Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation.Semantic proximity Read ↗

Competition between glutathione and protein thiols for disulphide-bond formation.Semantic proximity Read ↗

The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix.Semantic proximity Read ↗

Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes.Semantic proximity Read ↗

Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System.Semantic proximity Read ↗

Nuclear monothiol glutaredoxins of Saccharomyces cerevisiae can function as mitochondrial glutaredoxins.Semantic proximity Read ↗

A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis.Semantic proximity Read ↗

Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant.Semantic proximity Read ↗

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species.Semantic proximity Read ↗

Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes.Semantic proximity Read ↗

Tsa1 is the dominant peroxide scavenger and a source of H2O2-dependent GSSG production in yeast.Semantic proximity Read ↗

A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.