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Article

Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae.

The Journal of biological chemistry - 30 Oct 2015

Bankapalli Kondalarao, Saladi SreeDivya, Awadia Sahezeel S, Goswami Arvind Vittal, Samaddar Madhuja, D'Silva Patrick

Abstract excerpt

Methylglyoxal (MG) is a reactive metabolic intermediate generated during various cellular biochemical reactions, including glycolysis. The accumulation of MG indiscriminately modifies proteins, including important cellular antioxidant machinery, leading to severe oxidative stress, which is implicated in multiple neurodegenerative disorders, aging, and cardiac disorders. Although cells possess efficient glyoxalase...

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Identifiers

PMID: 26370081
DOI: 10.1074/jbc.M115.673624
PMCID: PMC4646309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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