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Article

Glutathione regulates the expression of gamma-glutamylcysteine synthetase via the Met4 transcription factor.

Molecular microbiology - 1 Oct 2002

Wheeler Glen L, Quinn Kathryn A, Perrone Gabriel, Dawes Ian W, Grant Chris M

Abstract excerpt

Our previous studies have shown that glutathione is an essential metabolite in the yeast Saccharomyces cerevisiae because a mutant deleted for GSH1, encoding the first enzyme in gamma-l-glutamyl-l-cysteinylglycine (GSH) biosynthesis, cannot grow in its absence. In contrast, strains deleted for GSH2, encoding the second step in GSH synthesis, grow poorly as the dipeptide intermediate, gamma-glutamylcysteine, can...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12406228
DOI: 10.1046/j.1365-2958.2002.03174.x

Genes

CDC34

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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