Article
Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae.
Current genetics - 1 May 1996
Grant C M, MacIver F H, Dawes I W
Abstract excerpt
Glutathione (GSH) is an abundant cellular thiol which has been implicated in numerous cellular processes and in protection against stress caused by xenobiotics, carcinogens and radiation. Our experiments address the requirement for GSH in yeast, and its role in protection against oxidative stress. Mutants which are unable to synthesis GSH due to a gene disruption in GSH 1, encoding the enzyme for the first step...
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