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Article

Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.

Antioxidants & redox signaling - 1 Oct 2011

Lubos Edith, Loscalzo Joseph, Handy Diane E

Abstract excerpt

Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can cause oxidative damage to DNA, proteins, and membrane lipids. Glutathione peroxidase-1 (GPx-1) is an intracellular antioxidant enzyme that enzymatically reduces hydrogen peroxide to water to limit its harmful effects. Certain reactive...

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Identifiers

PMID: 21087145
DOI: 10.1089/ars.2010.3586
PMCID: PMC3159114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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