Article
Requirement of glutathione for Sod1 activation during lifespan extension.
Yeast (Chichester, England) - 1 Jan 2011
Mannarino Sérgio C, Vilela Leonardo F, Brasil Aline A, Aranha Juliana N, Moradas-Ferreira Pedro, Pereira Marcos D, Costa Vítor, Eleutherio Elis C A
Abstract excerpt
It has been shown that the activation of cytosolic superoxide dismutase (Sod1) in Saccharomyces cerevisiae is only dependent on Ccs1, which is responsible for insertion of copper into the enzyme catalytic center, and that glutathione (GSH) is not necessary for this process. In this work, we addressed an important role of GSH in Sod1 activation by a Ccs1-dependent mechanism during oxidative stress and its role in...
Topics
- Chronology as Topic
- Copper
- Gene Expression Regulation, Fungal
- Glutaredoxins
- Glutathione
- Molecular Chaperones
- Mutation
- Oxidative Stress
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Superoxide Dismutase
- Vitamin K 3