Article
Molecular defects that cause loss of polysialic acid in the complementation group 2A10.
The Journal of biological chemistry - 20 Oct 2000
Windfuhr M, Manegold A, Muhlenhoff M, Eckhardt M, Gerardy-Schahn R
Abstract excerpt
Polysialic acid (PSA) is a dynamically regulated posttranslational modification of the neural cell adhesion molecule (NCAM), which modulates NCAM binding functions. PSA biosynthesis is catalyzed by two polysialyltransferases, ST8SiaII and ST8SiaIV. The catalytic mechanisms of these enzymes are unknown. In Chinese hamster ovary cells, ST8SiaIV is responsible for PSA expression. In the complementation group 2A10,...
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