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Article

Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule.

The Journal of biological chemistry - 11 Feb 2000

Close B E, Tao K, Colley K J

Abstract excerpt

Polysialyltransferase-1 (PST; ST8Sia IV) is one of the alpha2, 8-polysialyltransferases responsible for the polysialylation of the neural cell adhesion molecule (NCAM). The presence of polysialic acid on NCAM has been shown to modulate cell-cell and cell-matrix interactions. We previously reported that the PST enzyme itself is modified by alpha2,8-linked polysialic acid chains in vivo. To understand the role of...

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PMID: 10660622
DOI: 10.1074/jbc.275.6.4484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule.PMID 10660622Read ↗

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The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.Semantic proximity Read ↗

Specific amino acids in the first fibronectin type III repeat of the neural cell adhesion molecule play a role in its recognition and polysialylation by the polysialyltransferase ST8Sia IV/PST.Semantic proximity Read ↗

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Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX.Semantic proximity Read ↗

ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes.Semantic proximity Read ↗

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