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Article

Roles of BRCA1 and its interacting proteins.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Aug 2000

Deng C X, Brodie S G

Abstract excerpt

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules, including tumor suppressors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell-cycle regulators (cyclins and cyclin-dependent kinases), transcriptional...

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Source

Identifiers

PMID: 10918303
DOI: 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B

Genes

BRCA1
ATM
BRCA2
RAD50
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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