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Article

Dental tissue changes in juvenile and adult mice with osteogenesis imperfecta.

Anatomical record (Hoboken, N.J. : 2007) - 1 Mar 2024

Moore Jacob C, Husain Tooba S, Huston Lila A, Steele Ashley T, Organ Jason M, Gonzales Lauren A, Menegaz Rachel A, Handler Emma K

Abstract excerpt

Osteogenesis imperfecta (OI), a disorder of type I collagen, causes skeletal deformities as well as defects in dental tissues, which lead to increased enamel wear and smaller teeth with shorter roots. Mice with OI exhibit similar microstructural dentin changes, including reduced dentin tubule density and dentin cross-sectional area. However, the effects of these mutations on gross dental morphology and dental...

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PMID: 37638385
DOI: 10.1002/ar.25306

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