Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Makings of a brittle bone: Unexpected lessons from a low protein diet study of a mouse OI model.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2000

Mertz E L, Makareeva E, Mirigian L S, Koon K Y, Perosky J E, Kozloff K M, Leikin S

Abstract excerpt

Glycine substitutions in type I collagen appear to cause osteogenesis imperfecta (OI) by disrupting folding of the triple helix, the structure of which requires Gly in every third position. It is less clear, however, whether the resulting bone malformations and fragility are caused by effects of intracellular accumulation of misfolded collagen on differentiation and function of osteoblasts, effects of secreted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcification, Physiologic
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Collagen Type I

Share to Diet, Protein-Restricted

Share to Disease Models, Animal

Share to Osteoblasts

Share to Osteogenesis Imperfecta

Share to Protein Folding

Source

Open in PubMed Open full text

Identifiers

PMID: 27039252
DOI: 10.1016/j.matbio.2016.03.005
PMCID: PMC5061452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Makings of a brittle bone: Unexpected lessons from a low protein diet study of a mouse OI model.PMID 27039252Read ↗

Pleotropic effects of a recessive C <i>OL1α2</i> mutation occurring in a mouse model of severe osteogenesis imperfectaSemantic proximity Read ↗

Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta.Semantic proximity Read ↗

Morphological and mechanical characterization of bone phenotypes in the Amish G610C murine model of osteogenesis imperfecta.Semantic proximity Read ↗

Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)-G610C Mouse Model of Osteogenesis Imperfecta.Semantic proximity Read ↗

Characterization of a Novel Col1a1G643S/+ Osteogenesis Imperfecta Mouse Model with Insights into Skeletal Phenotype, Fragility, and Therapeutic Evaluations.Semantic proximity Read ↗

A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.Semantic proximity Read ↗

Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta.Semantic proximity Read ↗

The material basis for reduced mechanical properties in oim mice bones.Semantic proximity Read ↗

Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model.Semantic proximity Read ↗

Type 1 collagen: Synthesis, structure and key functions in bone mineralization.Semantic proximity Read ↗

Osteogenesis imperfecta: prospects for molecular therapeutics.Semantic proximity Read ↗

Exploration of the skeletal phenotype of the Col1a1 +/Mov13 mouse model for haploinsufficient osteogenesis imperfecta type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.