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DNA topology and topoisomerases

1 Jan 2009

Abstract excerpt

DNA is essentially an extremely long double-stranded rope in which the two strands are wound about one another. As a result, topological properties of the genetic material, including DNA underwinding and overwinding, knotting, and tangling, profoundly influence virtually every major nucleic acid process. Despite the importance of DNA topology, it is a conceptionally difficult subject to teach, because it requires...

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PMID: 19225573
DOI: 10.1002/bmb.20244

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