Article
Repair of helix-stabilizing anthramycin-N2 guanine DNA adducts by UVRA and UVRB proteins.
Journal of molecular biology - 20 Aug 1991
Tang M S, Nazimiec M E, Doisy R P, Pierce J R, Hurley L H, Alderete B E
Abstract excerpt
The transfectivity of anthramycin (Atm)-modified phi X174 replicative form (RF) DNA in Escherichia coli is lower in uvrA and uvrB mutant cells but much higher in uvrC mutant cells compared to wild-type cells. Pretreatment of the Atm-modified phage DNA with purified UVRA and UVRB significantly increases the transfectivity of the DNA in uvrA or uvrB mutant cells. This pretreatment greatly reduces the UVRABC...
Topics
- Adenosine Triphosphatases
- Anthramycin
- Apurinic Acid
- Bacterial Proteins
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA, Bacterial
- DNA, Viral
- DNA-Binding Proteins
- Endodeoxyribonucleases