Article

The general transcription factor TFIIB is a target for transcriptome control during cellular stress and viral infection

2024-01-17

Abstract excerpt

Many stressors, including viral infection, induce a widespread suppression of cellular RNA polymerase II (RNAPII) transcription, yet the mechanisms underlying transcriptional repression are not well understood. Here we find that a crucial component of the RNA polymerase II holoenzyme, general transcription factor IIB (TFIIB), is targeted for post-translational turnover by two pathways, each of which contribute to...

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Literature Corpus work: e3eac85b-cbc1-55b0-bbc0-73378c485e33
DOI: 10.1101/2024.01.16.575933

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