Article
Tissue mitochondrial DNA changes. A stochastic system.
Annals of the New York Academy of Sciences - 1 Jun 2000
Kopsidas G, Kovalenko S A, Heffernan D R, Yarovaya N, Kramarova L, Stojanovski D, Borg J, Islam M M, Caragounis A, Linnane A W
Abstract excerpt
Several lines of evidence support the view that the bioenergetic function of the mitochondria in postmitotic tissue deteriorates during normal aging. Skeletal muscle is one such tissue that undergoes age-related fiber loss and atrophy and an age-associated rise in the number of cytochrome c oxidase (COX) deficient fibers. With such metabolic pressure placed on skeletal muscle it would be an obvious advantage to...
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