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Decline in skeletal muscle mitochondrial function with aging in humans

30 Mar 2005

Abstract excerpt

Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are reported to accelerate aging in mice. We determined whether aging results in increased DNA oxidative damage and reduced mtDNA abundance and mitochondrial function in skeletal muscle of human subjects. Studies performed in 146 healthy men and women aged 18-89 yr demonstrated that mtDNA and mRNA abundance and mitochondrial ATP production all...

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PMID: 15800038
DOI: 10.1073/pnas.0501559102

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