Article
Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention.
Mutation research - 1 Sept 1992
Linnane A W, Zhang C, Baumer A, Nagley P
Abstract excerpt
A comprehensive hypothesis concerning the contribution of mitochondrial DNA (mtDNA) mutations to the human ageing process is reviewed and the implications for cellular bioenergy loss and pharmacological therapy are considered. The central idea is that random mutations in the population of mtDNA molecules of each cell occur throughout life, and that this is a major contributor to the gradual loss of cellular...
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