Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention.

doi:10.1016/0921-8734(92)90023-i

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Article

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention.

Mutation research - 1 Sept 1992

Linnane A W, Zhang C, Baumer A, Nagley P

Abstract excerpt

A comprehensive hypothesis concerning the contribution of mitochondrial DNA (mtDNA) mutations to the human ageing process is reviewed and the implications for cellular bioenergy loss and pharmacological therapy are considered. The central idea is that random mutations in the population of mtDNA m...

Topics

Adult
Aged
Aging
Animals
Base Sequence
DNA, Mitochondrial
Energy Metabolism
Genome, Human
Humans
Infant
Infant, Newborn
Middle Aged
Molecular Sequence Data
Mutation
Repetitive Sequences, Nucleic Acid
Sequence Deletion

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