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Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging.

Current environmental health reports - 1 Dec 2021

Leuthner Tess C, Meyer Joel N

Abstract excerpt

PURPOSE OF REVIEW: Mitochondrial dysfunction is a hallmark of aging. Mitochondrial genome (mtDNA) instability contributes to mitochondrial dysfunction, and mtDNA mutagenesis may contribute to aging. However, the origin of mtDNA mutations remains somewhat controversial. The goals of this review are to introduce and review recent literature on mtDNA mutagenesis and aging, address recent animal and epidemiological...

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Identifiers

PMID: 34761353
DOI: 10.1007/s40572-021-00329-1
PMCID: PMC8826492

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