Mitochondrial DNA mutation associated with aging and degenerative disease.

doi:10.1111/j.1749-6632.1992.tb27440.x

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Article

Mitochondrial DNA mutation associated with aging and degenerative disease.

Annals of the New York Academy of Sciences - 26 Dec 1992

Nagley P, Mackay I R, Baumer A, Maxwell R J, Vaillant F, Wang Z X, Zhang C, Linnane A W

Abstract excerpt

Previous theories of aging based on somatic mutation neglected mtDNA, which has a high propensity for mutational error. Knowledge of yeast mtDNA mutations and their functional effects, and of human mtDNA mutations identified in the mitochondrial cytopathies, provides for a concept of aging based...

Topics

Aging
Animals
DNA, Mitochondrial
Energy Metabolism
Humans
Mutation
Tissue Distribution

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