Article
Mitochondrial DNA mutation associated with aging and degenerative disease.
Annals of the New York Academy of Sciences - 26 Dec 1992
Nagley P, Mackay I R, Baumer A, Maxwell R J, Vaillant F, Wang Z X, Zhang C, Linnane A W
Abstract excerpt
Previous theories of aging based on somatic mutation neglected mtDNA, which has a high propensity for mutational error. Knowledge of yeast mtDNA mutations and their functional effects, and of human mtDNA mutations identified in the mitochondrial cytopathies, provides for a concept of aging based on the cumulative effect of mutations affecting human mtDNA. An essential feature of this concept is heteroplasmy,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.