Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing.

doi:10.1016/0921-8734(92)90025-k

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Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing.

Mutation research - 1 Sept 1992

Bittles A H

Abstract excerpt

Current experimental evidence on the role of mitochondrial DNA mutation in ageing is assessed alongside reports implicating other genetic and non-genetic causes, including inter-relationships between the mitochondrial and nuclear genomes and their potential effect on mitochondrial structure and function. The role of a 5-kb mtDNA deletion, identified as age-dependent in a variety of human and other mammalian...

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Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing.

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