Article
Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing.
Mutation research - 1 Sept 1992
Bittles A H
Abstract excerpt
Current experimental evidence on the role of mitochondrial DNA mutation in ageing is assessed alongside reports implicating other genetic and non-genetic causes, including inter-relationships between the mitochondrial and nuclear genomes and their potential effect on mitochondrial structure and function. The role of a 5-kb mtDNA deletion, identified as age-dependent in a variety of human and other mammalian...
Topics
- Aging
- Animals
- Cellular Senescence
- DNA, Mitochondrial
- Free Radicals
- Humans
- Mammals
- Mutation