Article

Genetic resistance to DEHP-induced transgenerational endocrine disruption

2018-11-19

Abstract excerpt

Di(2-ethylhexyl)phthalate (DEHP) interferes with sex hormones signaling pathways (SHP). C57BL/6J mice prenatally exposed to DEHP develop a testicular dysgenesis syndrome (TDS) at adulthood, but similarly-exposed FVB/N mice are not affected. Here we aim to understand the reasons behind this drastic difference that should depend on the genome of the strain. In both backgrounds, pregnant female mice received per os...

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Literature Corpus work: b9c4ec7e-f9c7-579c-a4ad-d064d4716986
DOI: 10.1101/474155

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