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Article

A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State.

EBioMedicine - 1 Oct 2015

Liu Ying, Yen Hai-Yun, Austria Theresa, Pettersson Jonas, Peti-Peterdi Janos, Maxson Robert, Widschwendter Martin, Dubeau Louis

Abstract excerpt

Predisposition to breast and extrauterine Müllerian carcinomas in BRCA1 mutation carriers is due to a combination of cell-autonomous consequences of BRCA1 inactivation on cell cycle homeostasis superimposed on cell-nonautonomous hormonal factors magnified by the effects of BRCA1 mutations on hormonal changes associated with the menstrual cycle. We used the Müllerian inhibiting substance type 2 receptor (Mis2r)...

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Source

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Identifiers

PMID: 26629527
DOI: 10.1016/j.ebiom.2015.08.034
PMCID: PMC4634618

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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