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Article

Strain-Specific Differences in the Mechanisms of Progesterone Regulation of Murine Mammary Gland Development

6 Nov 2008

Abstract excerpt

Progesterone (P) is required for normal mammary gland development, and is implicated in the etiology of mammary cancer in rodents and humans. We analyzed mammary gland developmental responses to P and estrogen (E) in two strains of mice (BALB/c and C57BL/6) that exhibit differences in ductal development at sexual maturity and alveologenesis during pregnancy. C57BL/6 mice exhibited reduced proliferative and...

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PMID: 18988671
DOI: 10.1210/en.2008-1459

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