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Differences in oocyte development and estradiol sensitivity among mouse strains

21 Oct 2009

Abstract excerpt

Mouse oocytes develop in clusters of interconnected cells called germline cysts. Shortly after birth, the majority of cysts break apart and primordial follicles form, consisting of one oocyte surrounded by granulosa cells. Concurrently, oocyte number is reduced by two-thirds. Exposure of neonatal females to estrogenic compounds causes multiple oocyte follicles that are likely germline cysts that did not break...

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PMID: 19846484
DOI: 10.1530/rep-09-0392

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