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Article

Genetic variation in susceptibility to endocrine disruption by estrogen in mice.

Science (New York, N.Y.) - 20 Aug 1999

Spearow J L, Doemeny P, Sera R, Leffler R, Barkley M

Abstract excerpt

Large (more than 16-fold) differences in susceptibility to disruption of juvenile male reproductive development by 17beta-estradiol (E2) were detected between strains of mice. Effects of strain, E2 dose, and the interaction of strain and E2 dose on testes weight and spermatogenesis were all highly significant (P < 0.0001). Spermatid maturation was eliminated by low doses of E2 in strains such as C57BL/6J and...

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Source

Identifiers

PMID: 10455051
DOI: 10.1126/science.285.5431.1259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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