Article
Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.
Proceedings of the National Academy of Sciences of the United States of America - 9 May 2000
Gordon M S, Kato R M, Lansigan F, Thompson A A, Wall R, Rawlings D J
Abstract excerpt
Chronic lymphocytic leukemia (CLL) B cells characteristically exhibit low or undetectable surface B cell receptor (BCR) and diminished responses to BCR-mediated signaling. These features suggest that CLL cells may have sustained mutations affecting one or more of the BCR proteins required for receptor surface assembly and signal transduction. Loss of expression and mutations in the critical BCR protein B29...
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