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Article

A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.

Nucleic acids research - 1 Jan 2004

Singh Nongmaithem Sadananda, Varshney Umesh

Abstract excerpt

The bacterial ssrA gene codes for a dual function RNA, tmRNA, which possesses tRNA-like and mRNA-like regions. The tmRNA appends an oligopeptide tag to the polypeptide on the P-site tRNA by a trans-translation process that rescues ribosomes stalled on the mRNAs and targets the aberrant protein for degradation. In cells, processing of the stalled ribosomes is also pioneered by drop-off of peptidyl-tRNAs. The ester...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15547251
DOI: 10.1093/nar/gkh924
PMCID: PMC534616

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coli.PMID 15547251Read ↗

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