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Article

Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Hayes Christopher S, Bose Baundauna, Sauer Robert T

Abstract excerpt

The SsrA or tmRNA quality control system intervenes when ribosomes stall on mRNAs and directs the addition of a C-terminal peptide tag that targets the modified polypeptide for degradation. Although hundreds of SsrA-tagged proteins can be detected in cells when degradation is prevented, most of these species have not been identified. Consequently, the mRNA sequence determinants that cause ribosome stalling and...

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Source

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Identifiers

PMID: 11891313
DOI: 10.1073/pnas.052707199
PMCID: PMC122542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli.PMID 11891313Read ↗

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Arginine-rich C9ORF72 ALS Proteins Stall Ribosomes in a Manner Distinct From a Canonical Ribosome-Associated Quality Control SubstrateSemantic proximity Read ↗

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