Article
New Insight into P-Glycoprotein as a Drug Target
2012-12-01
Abstract excerpt
Multidrug resistance (MDR) of cancer tissue is a phenomenon in which cancer cells exhibit reduced sensitivity to a large group of unrelated drugs with different mechanisms of pharmacological activity. Mechanisms that reduce cell sensitivity to damage induced by a variety of chemicals were found to be caused by diverse, albeit well-defined, phenotypic alterations. The molecular basis of MDR commonly involves overex...
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Identifiers and source
- Literature Corpus work
- 3ff80244-840c-5d96-b052-eb52b3674f8f
- DOI
- 10.2174/1871520611307010159