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Article

Expression of multidrug resistance P-glycoprotein in myeloid progenitor cells of different phenotype: comparison between normal bone marrow cells and leukaemia cells.

British journal of haematology - 1 Apr 1996

Takeshita A, Shinjo K, Ohnishi K, Ohno R

Abstract excerpt

We examined the multidrug resistant P-glycoprotein (P-gp) on normal bone marrow (BM) cells and acute myeloid leukaemia (AMI) cells, using newly devised flow cytometric multi-parameter analysis with CD33, CD34 and MRK16 monoclonal antibodies. In both normal BM cells and AML cells, CD34+CD33- cells expressed P-gp strongly, CD34+CD33- cells moderately, and CD34-CD33+ cells weakly. Acute promyelocytic leukaemia,...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Acute Disease
Antigens, CD
Antigens, CD34
Antigens, Differentiation, Myelomonocytic
Bone Marrow Cells
Drug Resistance, Multiple
Flow Cytometry
Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukemia, Myeloid

Membrane Glycoproteins

Phenotype

Sialic Acid Binding Ig-like Lectin 3

Source

Identifiers

PMID: 8611458
DOI: 10.1046/j.1365-2141.1996.459996.x

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