Article
[Multidrug resistance in acute leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Aug 1996
Takeshita A, Ohno R
Abstract excerpt
We examined the multidrug resistance (MDR) P-glycoprotein (P-gp) on normal bone marrow (BM) cells and acute myeloid leukaemia (AML) cells, using newly devised flow cytometric multi-parameter analysis with CD33, CD34 and MRK16 monoclonal antibodies. With biotinylated MRK16 and a Streptavidin-RED670 (SA-RED670) conjugate, we succeeded in the detection of a small amount of P-gp on these cells. In normal bone marrow...
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