Article
Association of a single nucleotide variant in the human tumour necrosis factor alpha promoter region with decreased bone mineral density.
Annals of human biology - 1 Jan 2000
Ota N, Nakajima T, Ezura Y, Iwasaki H, Suzuki T, Hosoi T, Orimo H, Inoue S, Ito H, Emi M
Abstract excerpt
BACKGROUND: Tumour necrosis factor alpha (TNFalpha) has come to be regarded as a potential osteoporotic factor, because it has stimulatory effects on cells of the osteoclast lineage and has been implicated in the pathogenesis of bone loss associated with oestrogen deficiency. We recently described genetic linkage between the TNFalpha locus and human osteoporosis by sib-pair analysis. However, the molecular...
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