Article
Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women.
Bone - 1 Aug 2003
Ishida Ryota, Ezura Yoichi, Emi Mitsuru, Kajita Mitsuko, Yoshida Hideo, Suzuki Takao, Hosoi Takayuki, Inoue Satoshi, Shiraki Masataka, Ito Hiromoto, Orimo Hajime
Abstract excerpt
Osteoporosis, a multifactorial common disease, is believed to result from the interplay of multiple environmental and genetic factors that regulate bone mineral density (BMD). Tumor necrosis factor receptor associated factor-interacting protein (I-TRAF) is an essential effecter of the tumor necrosis factor receptor-signaling cascade, one of the most potent bone-resorbing systems. In genetic studies of 382...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.