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Article

The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation.

Molecular and cellular biology - 1 Aug 2000

Wennerberg K, Armulik A, Sakai T, Karlsson M, Fässler R, Schaefer E M, Mosher D F, Johansson S

Abstract excerpt

We have previously shown that mutation of the two tyrosines in the cytoplasmic domain of integrin subunit beta1 (Y783 and Y795) to phenylalanines markedly reduces the capability of beta1A integrins to mediate directed cell migration. In this study, beta1-dependent cell spreading was found to be delayed in GD25 cells expressing beta1A(Y783/795F) compared to that in wild-type GD25-beta1A. Focal adhesion kinase...

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Identifiers

PMID: 10891511
DOI: 10.1128/MCB.20.15.5758-5765.2000
PMCID: PMC86053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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