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Article

beta1-integrin cytoplasmic subdomains involved in dominant negative function.

Molecular biology of the cell - 1 Apr 1998

Retta S F, Balzac F, Ferraris P, Belkin A M, Fässler R, Humphries M J, De Leo G, Silengo L, Tarone G

Abstract excerpt

The beta1-integrin cytoplasmic domain consists of a membrane proximal subdomain common to the four known isoforms ("common" region) and a distal subdomain specific for each isoform ("variable" region). To investigate in detail the role of these subdomains in integrin-dependent cellular functions, we used beta1A and beta1B isoforms as well as four mutants lacking the entire cytoplasmic domain (beta1TR), the...

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Identifiers

PMID: 9529373
DOI: 10.1091/mbc.9.4.715
PMCID: PMC25300

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Source receipt: pubmed, retrieved 7 Sept 2026.

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